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• Cancer Drugs

- K -

• karenitecin

A synthetic silicon-containing agent related to camptothecin with antineoplastic properties. Karenitecin stabilizes the cleavable complex between topoisomerase I and DNA, resulting in DNA breaks and consequently triggering apoptosis. Because it is lipophilic, karenitecin exhibits enhanced tissue penetration and bio-availability compared to water-soluble camptothecins.



• Keoxifene

(Other name for: raloxifene)



• Kepivance

(Other name for: palifermin)



• ketamine hydrochloride

The hydrochloride salt of a synthetic nonbarbiturate anesthetic derivative of cyclohexanone. Although its mechanism of action is not well understood, ketamine appears to block NMDA receptors (N-methyl-D-aspartate) and may interact with sigma receptors, thereby reducing pain perception and inducing sedation.



• ketoconazole

A synthetic derivative of phenylpiperazine with broad antifungal properties and potential antineoplastic activity. Ketoconazole inhibits sterol 14-a-dimethylase, a microsomal cytochrome P450-dependent enzyme, thereby disrupting synthesis of ergosterol, an important component of the fungal cell wall.



• keyhole limpet hemocyanin

A natural protein isolated from the marine mollusc keyhole limpet. Keyhole limpet hemocyanin is an immunogenic carrier protein that, in vivo, increases antigenic immune responses to haptens and other weak antigens such as idiotype proteins.



• Kineret

(Other name for: anakinra)



• Komed HC

(Other name for: hydrocortisone)



• KOS-953

(Other name for: 17-N-allylamino-17-demethoxygeldanamycin)



• KRN5500

A semisynthetic derivative of the nucleoside-like antineoplastic antibiotic spicamycin, originally isolated from the bacterium Streptomyces alanosinicus. KRN 5500 inhibits protein synthesis by interfering with endoplasmic reticulum and Golgi apparatus functions. This agent also induces cell differentiation and caspase-dependent apoptosis.



• Kynacyte

(Other name for: L-threo-dihydrosphingosine)



• Kytril

(Other name for: granisetron hydrochloride)